Leadership

Ivet Bahar, Principal Investigator, MMBioS Director and TR&D1 Leader

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Dr. Bahar, MMBioS PI and Director, is Distinguished Professor and John K. Vries Chair of the Department of Computational and Systems Biology, at the University of Pittsburgh, School of Medicine, and Associate Director of the University of Pittsburgh Drug Discovery Institute (UPDDI). She is the co-founder, with Robert F. Murphy (CMU), of the Ph.D. Program in Computational Biology (CPCB) jointly offered by Carnegie Mellon University and the University of Pittsburgh. She has authored more than 230 publications in scientific journals, which received more than 9,000 citations (H index = 50). She is an elected member of the European Molecular Biology Organization (EMBO) since 2001.

Dr. Bahar's laboratory is dedicated to the study of biomolecular systems dynamics at multiple scales, with emphasis on a mechanistic modeling of complex interactions and molecular intervention methods. She pioneered the use of elastic network models as powerful tools to gain an understanding of cooperative motions and molecular mechanisms of biological function. She is leading the TR&D1 (Molecular Modeling) project of the MMBioS Center, focusing in particular on the mechanisms of function of transporters and receptors involved in neurosignaling and their interactions with small molecules including neurotransmitters, ions, psychostimulants and drugs, with the goals of identifying key variables and parameters to be accounted for in cellular simulations and assessing the effects of these interactions on cell signaling and regulation events.