The National Center for Multiscale Modeling of Biological Systems (MMBioS) develops tools to advance and facilitate cutting-edge research at the interface between high performance computing and the life sciences. Our overarching goal is the predictive multi-scale modeling of the spatiotemporal organization and evolution of neurosignaling systems and events. The advances made here will impact the research activities of a broad group of scientists, from molecular and structural biologists to cell and systems biologists. These advances will also facilitate the translation of basic tools to biomedical and clinical research by establishing and then disseminating a computational framework which integrates theory with experiment and models with methods originating from different disciplines.
We are building on the state-of-the-art technology and methods at the forefront of molecular and cellular modeling that have been developed at our partner sites. Rapid advances in experimental technologies which enable the study of events ranging from single molecule dynamics to tissue level organization also create multi-scale modeling challenges. We are addressing these emerging challenges, including high performance computing, data storage and networking needs.
Software & Servers
MMBioS is a joint Center between the University of Pittsburgh, the Pittsburgh Supercomputing Center, Carnegie Mellon University, and the Salk Institute for Biological Studies.
An important task for understanding how cells are organized is determining which components have spatial patterns that are related to each other. Read more
Using a combination of diffeomorphic methods and improved cell segmentation, we developed a CellOrganizer pipeline for use in DPB4 to construct models of the 4D distributions of actin and 8 of its regulators during the response of T cells to antigen presentation. Read more