The National Center for Multiscale Modeling of Biological Systems (MMBioS) develops tools to advance and facilitate cutting-edge research at the interface between high performance computing and the life sciences. Our overarching goal is the predictive multi-scale modeling of the spatiotemporal organization and evolution of neurosignaling systems and events. The advances made here will impact the research activities of a broad group of scientists, from molecular and structural biologists to cell and systems biologists. These advances will also facilitate the translation of basic tools to biomedical and clinical research by establishing and then disseminating a computational framework which integrates theory with experiment and models with methods originating from different disciplines.
We are building on the state-of-the-art technology and methods at the forefront of molecular and cellular modeling that have been developed at our partner sites. Rapid advances in experimental technologies which enable the study of events ranging from single molecule dynamics to tissue level organization also create multi-scale modeling challenges. We are addressing these emerging challenges, including high performance computing, data storage and networking needs.
Software & Servers
|April 28 - April 30, 2014|
Workshop: Computational Methods for Spatially Realistic Microphysiological Simulations
|May 19 - May 23, 2014|
Hands-on Workshop on Computational Biophysics
Junction Crossing Ahead
GltPh Intracellular Gating
Our recent study highlights the role of the helical hairpin HP2 as an intracellular gate, in addition to its role as an extracellular gate. We have elucidated the pathway of aspartate release... read more.